Champions league last-16 tie between Valencia vs Atlanta on 10 March will be played behind closed doors in an effort to contain the spread of coronavirus.
Spain’s health ministry says it wants to avoid “large gatherings of fans”.
Serie A side Atalanta hold a 4-1 lead after last month’s first leg in Italy.
Los Ches will have to make do without the support from their fans when they attempt to overturn a 4-1 aggregate scoreline in the second leg of their last-16 tie on March 10.
Juventus’ Champions League tie against Lyon on 17 March is also likely to be affected after the Italian government decreed all sport be played behind closed doors until 3 April.
This came after Spanish Health Minister, Salvador Illa, recommend that all sporting events that include teams from zones designated as high-risk for coronavirus, such as northern Italy, should be held in empty stadiums.
Spain has 237 reported cases of coronavirus so far, with three deaths.
Italy is the worst-hit European country with some 2,706 cases and 107 deaths so far.
Last Thursday, Inter Milan’s Europa League victory over Ludogorets was played behind closed doors at San Siro Stadium.
Also, England’s Six Nations games against Italy on 14 and 15 March have also been postponed .